A Signaling View into the Inflammatory Tumor Microenvironment

The development of tumors requires an initiator event, usually exposure to DNA damaging agents that cause genetic alterations such as gene mutations or chromosomal abnormalities, leading deregulated cell proliferation. Although the mere stochastic accumulation further may tumor progression, it is now clear inflammatory microenvironment has a major tumor-promoting influence on initiated cells, in particular when chronic reaction already existed before was formed. Moreover, cells become mobilized response signals emanating from cells. In both cases, provides perceive by membrane receptors and transduce via downstream kinase cascades modulate multiple cellular processes respond with changes expression, metabolism, morphology. Cytokines, chemokines, growth factors are examples secreted immune fibroblast, endothelial mediate intricate cell-cell crosstalk microenvironment, which contributes increased cancer survival, phenotypic plasticity adaptation surrounding tissue conditions. Eventually, consequent extracellular matrix stiffness architecture, coupled additional alterations, fortify malignant progression priming them for invasion metastasis. Here, we provide overview current knowledge composition emphasis signal-transducing events mediating different aspects stromal cell-tumor communication ultimately lead progression.